Mueller marked his 400th Bundesliga appearance via opening the scoring with his 222nd league goal earlier than defender Upamecano, signed from Leipzig for this season, headed in his first purpose in the well-known red Bayern blouse.
Leroy Sané then planted a shot into the left nook at the hour mark.
Lewandowski, who on Tuesday equalled Gerd Mueller's record of 42 German league dreams in a calendar 12 months from 1972, capped a gala night with Bayern's fourth to say the new document outright.
This became Bayern's final suit earlier than the Bundesliga winter smash, and head instruct Julian Nagelsmann become pleased with the performance.
"We defended properly, pressed them tough, received quite a whole lot each ball in our personal half of, and we deserved to win with the aid of that margin," stated Nagelsmann.
The Bayern boss also praised Lewandowski's modern day file, "he truly merits it, particularly as he scored together with his weaker foot".
Bayern's lead on the top of the Bundesliga desk may be trimmed on Saturday by way of 2nd-positioned Borussia Dortmund, who are away to Hertha Berlin.
This turned into Wolfsburg's seventh instantly loss, piling the strain on new head educate Florian Kohfeldt, who most effective took charge at the stop of October after the sacking of predecessor Mark van Bommel.
"That hurts - we defended badly, particularly for the fourth intention, that wasn't on," fumed Kohfeldt, who now has the two-week smash to drill his crew.
In evaluation, this became Bayern's seventh straight victory in all competitions.
