Mauricio Pochettino's guys were given a supporting hand by a nightmarish show from Lille goalkeeper Ivo Grbic on the Stade Pierre-Mauroy.
Portuguese midfielder Danilo Pereira netted two times, whilst Presnel Kimpembe additionally were given on the scoresheet.
It changed into the best reaction for PSG after their French Cup go out on penalties at the palms of Nice in midweek.
Lille are languishing down in eleventh vicinity after a 7th defeat of their title defence.
The hosts needed to get something from the game to transport into the top half of of the table, however they made a calamitous start.
Grbic someway didn't acquire in Nuno Mendes' low pass notwithstanding being underneath no stress, and Danilo duly stabbed into an empty net to provide PSG a 10th-minute lead.
Hatem Ben Arfa, making his first start because closing April after his marvel move to Lille, installation Sven Botman to equalise before the half of-hour mark.
But PSG have been back in front in the thirty second minute as Grbic totally overlooked Messi's nook and Kimpembe bundled domestic from near range.
Messi grabbed his first intention of 2022 in slightly fortuitous instances, as a clearance ricocheted of his shins and played him in on purpose.
