Ole Gunnar Solskjaer is clinging to his job after United's humiliating 5-0 defeat at the hands of Liverpool last week. His side have taken just one point from the past 12 on offer.
Leaders Chelsea, Liverpool and defending champions City all have winnable matches this weekend while Leicester and Arsenal go head to head in an intriguing battle between two sides who have found their form.
AFP Sport looks at some of the main talking points ahead of the action.
Solskjaer on the brink
Solskjaer called his team's humbling by Jurgen Klopp's men at Old Trafford his "darkest day" as Red Devils boss.
