Juve kept up their one hundred percentage record in Group H, which they top by way of 3 points from European champions Chelsea, who were 1-0 winners at Malmo in Sweden earlier.
Massimiliano Allegri's facet are also nine factors clear of 0.33-located Zenit, meaning their area within the knockout phase is secured.
Dybala hit the post shortly earlier than firing home the opener within the 11th minute, although Zenit drew stage earlier than the half of-hour mark when Leonardo Bonucci headed a Vyacheslav Karavaev go into his own net.
However, Dybala restored Juve's lead in the 58th minute, changing a penalty after initially lacking most effective to be granted a retake because of encroachment.
Federico Chiesa, who had gained the penalty, made it three-1 for the two-time European Cup winners in the 73rd minute and Alvaro Morata were given their fourth.
Iran's Sardar Azmoun then pull one returned in stoppage time for Zenit, who nevertheless maintain a slender threat of pipping Chelsea to second vicinity.
