The 10 organization winners will stable qualification for football's global showpiece which kicks off on November 21, 2022. The 10 runners-up gets another threat to qualify in play-offs next March.
AFP Sport appears at what is up for grabs in the ultimate group games:
- Spain have all to play for -
Spain confirmed on their runs to the Euro 2020 semi-finals and the Nations League final that they may be again a force to be reckoned with. However, the 2010 global champions nevertheless have work to do to secure their region in Qatar from qualifying Group B.
Luis Enrique's facet sit 2nd, points behind leaders Sweden. They head to Athens on Thursday to play Greece, who held them to a 1-1 draw at domestic in March. Failure to win this time would provide Sweden the chance to clinch pinnacle spot with victory in Georgia.
Otherwise the institution might be decided while Spain host Sweden -- inclusive of a 40-year-antique Zlatan Ibrahimovic -- in Seville on Sunday.
- Italy, Dutch returned on big stage? -
European champions Italy, who did not qualify in 2018, aren't there yet both. With video games left in Group C they're locked on 14 points with Switzerland, and the edges clash on Friday in Rome, 5 months after Italy received 3-0 there while the groups met in Euro 2020's establishing sport.
Whoever wins may be left requiring only a factor of their final qualifier, with the Azzurri going to Northern Ireland on Monday at the same time as the Swiss host Bulgaria.
"We should not assume that we've got the whole thing to lose," stated train Roberto Mancini. "We recognise what we're capable of, and if we play our recreation I suppose we are able to carry out nicely. And we will have a laugh."