Betis take a seat 0.33 in La Liga with genuine hopes of qualifying for subsequent season's Champions League and in this form they may take some stopping within the cup.
They join Rayo Vallecano and Valencia within the semis, with Real Madrid facing Athletic Bilbao afterward Thursday for the last spot.
Madrid are organization favourites, mainly after Barcelona, Sevilla and Atletico Madrid have been all knocked out, but Betis appearance to be the finest chance now to Carlo Ancelotti's group sealing a Spanish double.
Betis have no longer reached the Copa del Rey final because they closing received the opposition in 2005.
Juanmi, who joined Betis from Real Sociedad in 2019, scored two times towards his former club at Anoeta but his opener owed plenty to a few first rate work by using William Carvalho, who burst via and then cut returned for his teammate to slot into the corner.
Adnan Januzaj had an equaliser for La Real ruled out earlier than 1/2-time after which shortly after it, Juanmi struck again, firing in along with his left foot after Alex Moreno raced onto a curving ball thru from Sergio Canales.
Betis made the rating greater emphatic within the remaining seven minutes as Willian Jose transformed a penalty after which Aitor Rubial, on off the bench, sprinted clean and smashed in to make it 4.