Salah's first-time finish at the returned put up inside the 69th minute were given his and his group's campaign in Cameroon up and running after they had misplaced 1-zero to Nigeria in their beginning Group D recreation.
However, Guinea-Bissau were left fuming after a lovely 82nd-minute strike with the aid of Mama Balde changed into dominated out following a VAR evaluate.
Egypt, who also hit the woodwork three times, will sense they deserved the victory on the balance of play and Carlos Queiroz's group now need most effective draw their last institution game against neighbours Sudan in Yaounde on Wednesday to guarantee safe passage to the remaining 16.
"It turned into a genuinely hard sport and we had been a little bit lucky with the foul," Salah admitted to broadcasters at the cease of the fit.
"We should win our subsequent game now to make sure we qualify and we are able to do our best to move as some distance as we are able to in the event."
Salah, who had not scored in any of his previous six appearances for Egypt this season, struck the publish with just 84 seconds performed.
The Liverpool celebrity was then involved at the start of the 18th-minute circulate that ended with Omar Marmoush cushioning the ball down for Mostafa Mohamed to ship any other shot off the upright.
Salah finally broke the deadlock halfway via the second half when he met Amr El Solia's floated ball to the returned publish with a primary-time cushioned volley that Guinea-Bissau goalkeeper Jonas Mendes may sense he have to have stored.
Balde thought he had equalised with a exceptional intention when he accumulated ownership at the left wing, cut internal and unleashed a awesome effort from simply inside the container into the a ways corner.
However the referee ruled out the goal after reviewing the photos, judging that Balde had grappled Egypt right-back Omar Kamal to the ground.