After missing the previous two games due to a thigh injury sustained while on international duty, Raphael Varane is back in action in what looks like a back three for Ole's men, with Harry Maguire and Victor Lindelof starting alongside him.
Here is how the two sides will start the match:
Spurs XI: Lloris, Emerson Royal, Romero, Dier, Davies, Skipp, Hojbjerg, Lo Celso, Lucas Moura, Son, Kane.
Subs: Gollini, Doherty, Reguilon, Sanchez, Rodon, Alli, Bergwijn, Tanganga, Ndombele.
Man United XI: De Gea, Wan-Bissaka, Lindelof, Varane, Maguire, Shaw, McTominay, Fred, Fernandes, Cavani, Ronaldo.