Thomas Tuchel's facet took the lead while Antonio Rudiger's handball went unpunished inside the construct-up to Chalobah's first half of opener at Stamford Bridge.
Juventus never recovered from that blow as Reece James, Callum Hudson-Odoi and Timo Werner struck after 1/2-time to send Chelsea to the top of Group H.
Chelsea are above Juventus on purpose distinction and could guarantee a first region finish in the event that they win at Zenit Saint Petersburg in their remaining group fixture on December eighth.
It was every other commanding display from Chelsea, who're unbeaten in 10 games in all competitions due to the fact losing 1-0 at Juventus in September.
James, one among three scorers on the night time to graduate from Chelsea's adolescents academy, became mainly dynamic at right wing-returned as the 21-year-antique matures right into a world-elegance expertise.
Tuchel's night wasn't absolutely problem unfastened as each N'Golo Kante and Ben Chilwell were forced off, with the latter's knee injury searching in particular regarding for the Premier League leaders beforehand of Manchester United's visit on Sunday.
Lacklustre Juventus had already certified for the remaining 16, but the defeat puts their hopes of completing top of the organization in intense jeopardy.
Chelsea's star striker Romelu Lukaku was lower back at the bench after his prolonged absence with an ankle injury.
But Lukaku wouldn't be wanted as Tuchel's guys tore Juventus apart.
Juventus striker Alvaro Morata became on familiar floor against his old membership, but the Spaniard did not get hold of a warm welcome.
