Peter Bosz's aspect, who've struggled in Ligue 1 this season, are hoping to win a major European trophy for the primary time this time period.
Paqueta produced the game's figuring out second simply earlier than the hour mark after a disappointing first half of, amassing Tanguy Ndombele's skip and slotting domestic.
The aim survived a VAR take a look at for offside, a couple of minutes earlier than the video assistant additionally ruled that Paqueta had no longer handled inside the region at the opposite give up of the pitch.
There was more drama deep into stoppage time, as Porto defender Chancel Mbemba had an effort dominated out for offside.
Lyon will now be confident of reserving their area inside the remaining-eight draw inside the second leg of the final-sixteen tie in France per week on Thursday.
Elsewhere, Eintracht Frankfurt secured an excellent 2-1 win at Real Betis of their first leg.
The Bundesliga membership took an early lead through Filip Kostic, earlier than Nabil Fekir levelled for Betis within the 30th minute.
Japan midfielder Daichi Kamada netted what proved to be the winner before half-time.
It might have been worse for Betis, who sit fifth in La Liga this season, as Frankfurt's Rafael Borre ignored a 2d-half penalty.
